HOW TO USE
Take this medication by mouth with or without food, usually once daily in the morning or as directed by your doctor. If you are using modafinil for shift work sleep disorder, take this medication 1 hour before you start your work shift or as directed by your doctor. If you are using this for apnea (OSAHS), continue your other current treatment (e.g., CPAP machine) unless your doctor tells you to stop.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
. Blurred vision.
. Dry mouth.
. Loss of appetite.
. Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain.
. Weakness or loss of strength (asthenia).
. Difficulty sleeping (insomnia).
. Anxiety and agitation.
. Pins and needles sensations (paraesthesia).
. Alteration in results of liver function tests.
. Unstable moods (emotional lability).
. Decreased sex drive.
. Chest pain.
. Changes in your heart rate or blood pressure.
. Skin reactions such as rash or itching (see warning above).
. Psychiatric reactions (see warning above).
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
This medicine may reduce the effectiveness of oral contraceptive pills and patches because it may speed up the breakdown (metabolism) of the hormones in the body. For this reason, women who are using hormonal contraceptives should use an additional method of contraception, such as condoms, to help prevent pregnancy. Alternatively, it may be more appropriate to use a different method of contraception altogether, particularly for women using this medicine long-term. Whichever method is used, effective contraception should be continued for two months after stopping treatment with modafinil. It is important for women to discuss contraception with their doctor before they start treatment with this medicine.
Antiepileptic medicines such as carbamazepine and phenobarbital may reduce the blood level of this medicine.
Modafinil may increase the blood level of the antiepileptic medicine phenytoin, and people taking both these medicines should have their phenytoin levels monitored.
Some products that may interact with this drug include: medications for high blood pressure (e.g., beta blockers such as atenolol/metoprolol, clonidine, guanabenz, methyldopa, prazosin), "blood thinners" (e.g., warfarin), street drugs (e.g., methamphetamine, MDMA-"ecstasy"), drugs that affect liver enzymes that remove modafinil from the body (e.g., azole antifungals such as itraconazole/ketoconazole, rifamycins such as rifabutin/rifampin, anti-seizure medications such as carbamazepine/phenobarbital).
Modafinil can speed up or slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs may include certain antidepressants (e.g., TCAs such as clomipramine/desipramine, SSRIs such as fluoxetine, fluvoxamine), cyclosporine, diazepam, phenytoin, propranolol, theophylline, triazolam.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients (e.g., pseudoephedrine, ephedra/ma huang) that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products.
Avoid drinking large amounts of beverages containing caffeine (e.g., coffee, tea, cola). Caffeine can increase the side effects of this medication.